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The addition of 234 hospital beds in private rooms will create a total of 339 beds across the expanded hospital.
The $116 million investment is expected to increase nursing capacity and add imaging options and medical office space.
The health system cites staffing shortages and smaller patient volumes for the consolidation.
UH says the move will centralize care and make way for new investigative technologies.
The cancer center is part of a larger $50 million campaign to improve cancer care and research in the region.
The largest investment is for an EmPATH unit that will provide a better environment for people with acute psychiatric crises.
Hawaii Pacific Health in Honolulu is planning on the redevelopment of the Straub Benioff Medical Center after receiving a $4 million donation.
Funds will be used for a new 14-story patient tower, updated technologies and additional residency and fellowship programs.
The 25,000-square-foot facility boasts upgraded technology as well as personalized care plans and a focus on research initiatives.
The collaboration is expected to reduce expenses for payers and patients as hospital-based procedures cost up to 167% more than ASCs.
